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Issue 96, 2012
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Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

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Abstract

The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.

Graphical abstract: Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

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Publication details

The article was received on 31 Aug 2012, accepted on 08 Oct 2012 and first published on 29 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36352F
Citation: Chem. Commun., 2012,48, 11781-11783
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    Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

    T. Métro, J. Bonnamour, T. Reidon, J. Sarpoulet, J. Martinez and F. Lamaty, Chem. Commun., 2012, 48, 11781
    DOI: 10.1039/C2CC36352F

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