Issue 94, 2012
From the journal:

Chemical Communications

Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083†

Fa-Guang Zhang,a   Xiao-Yan Zhu,a   Shen Li,a   Jing Niea  and  Jun-An Ma*ab  

* Corresponding authors

a Department of Chemistry, Tianjin University, Tianjin 300072, China
E-mail: majun_an68@tju.edu.cn
Fax: +86-22-2740-3475

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry (CAS), Shanghai 200032, China

Abstract

A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic α-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.

Graphical abstract: Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

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Article information

DOI
https://doi.org/10.1039/C2CC36307K
Article type
Communication
Submitted
30 Aug 2012
Accepted
12 Oct 2012
First published
23 Oct 2012

Chem. Commun., 2012,48, 11552-11554

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Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

F. Zhang, X. Zhu, S. Li, J. Nie and J. Ma, Chem. Commun., 2012, 48, 11552 DOI: 10.1039/C2CC36307K

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