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Issue 88, 2012
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Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry§

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Abstract

Toward new biotechnology by genetic alphabet expansion, we developed an efficient site-specific labeling method for large RNA molecules. The combination of unnatural base pair transcription and post-transcriptional modification by click chemistry enables simple RNA labeling with a wide variety of functional groups at desired positions, in a one-pot reaction.

Graphical abstract: Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry

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Publication details

The article was received on 30 Aug 2012, accepted on 18 Sep 2012 and first published on 24 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36293G
Chem. Commun., 2012,48, 10835-10837

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    Site-specific functionalization of RNA molecules by an unnatural base pair transcription system via click chemistry

    T. Ishizuka, M. Kimoto, A. Sato and I. Hirao, Chem. Commun., 2012, 48, 10835
    DOI: 10.1039/C2CC36293G

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