Issue 89, 2012
From the journal:

Chemical Communications

Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition†

Liangliang Zhang,a   Jingjin Zhao,a   Jianhui Jianga  and  Ruqin Yu*a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: rqyu@hnu.edu.cn
Fax: +86 731-88822782
Tel: +86 731-88822577

Abstract

Based on enzyme-regulated unmodified gold nanoparticle aggregation, a visual and homogeneous assay of adenosine deaminase (ADA) activity without any other coupling enzymes, aptamers or additional modifications has been developed. The present strategy is simple, cost-effective, high throughput, selective and sensitive for ADA with a detection limit of 0.8227 U Lāˆ’1.

Graphical abstract: Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition

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Article information

DOI
https://doi.org/10.1039/C2CC36240F
Article type
Communication
Submitted
28 Aug 2012
Accepted
23 Sep 2012
First published
25 Sep 2012

Chem. Commun., 2012,48, 10996-10998

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Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition

L. Zhang, J. Zhao, J. Jiang and R. Yu, Chem. Commun., 2012, 48, 10996 DOI: 10.1039/C2CC36240F

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