Issue 88, 2012
From the journal:

Chemical Communications

Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR†

Keisuke Maruyoshi,ab   Dinu Iuga,a   Oleg N. Antzutkin,ac   Amjad Alhalaweh,d   Sitaram P. Velagad  and  Steven P. Brown*a  

* Corresponding authors

a Department of Physics, University of Warwick, Coventry CV4 7AL, UK
E-mail: S.P.Brown@warwick.ac.uk
Fax: +44 (0)24 76150897
Tel: +44 (0)24 76574359

b Analytical & Quality Evaluation Research Laboratories, Daiichi Sankyo Co. Ltd., 1-12-1, Shinomiya, Hiratsuka-shi, Kanagawa, Japan

c Chemistry of Interfaces, Luleå University of Technology, Luleå, Sweden

d Department of Health Science, Luleå University of Technology, Luleå, Sweden

Abstract

Two-dimensional 1H double-quantum and 14N–1H & 1H–13C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH⋯Narom and CHarom⋯O[double bond, length as m-dash]C hydrogen-bonding interactions in the solid-state structure of an indomethacin–nicotinamide cocrystal, thus additionally proving cocrystal formation.

Graphical abstract: Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

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Article information

DOI
https://doi.org/10.1039/C2CC36094B
Article type
Communication
Submitted
22 Aug 2012
Accepted
19 Sep 2012
First published
21 Sep 2012

Chem. Commun., 2012,48, 10844-10846

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Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

K. Maruyoshi, D. Iuga, O. N. Antzutkin, A. Alhalaweh, S. P. Velaga and S. P. Brown, Chem. Commun., 2012, 48, 10844 DOI: 10.1039/C2CC36094B

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