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Issue 90, 2012
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Enabling Wittig reaction on site-specific protein modification

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Abstract

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting “aldehyde tag” was presented. A variety of functional groups could be introduced into the protein of interest.

Graphical abstract: Enabling Wittig reaction on site-specific protein modification

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Publication details

The article was received on 08 Aug 2012, accepted on 24 Sep 2012 and first published on 25 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35738K
Chem. Commun., 2012,48, 11079-11081

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    Enabling Wittig reaction on site-specific protein modification

    M. Han, D. Xiong and X. Ye, Chem. Commun., 2012, 48, 11079
    DOI: 10.1039/C2CC35738K

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