Issue 76, 2012

Enantioselective alkylation of β-keto phosphonates by direct use of diaryl methanols as electrophiles

Abstract

Enantioselective alkylation of β-keto phosphonates with diaryl methanols in the presence of catalytic amounts of copper(II) trifluoromethanesulfonate and an optically active ligand gives the corresponding alkylated products in good to high yields with a high enantioselectivity.

Graphical abstract: Enantioselective alkylation of β-keto phosphonates by direct use of diaryl methanols as electrophiles

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2012
Accepted
05 Aug 2012
First published
07 Aug 2012

Chem. Commun., 2012,48, 9528-9530

Enantioselective alkylation of β-keto phosphonates by direct use of diaryl methanols as electrophiles

M. Shibata, M. Ikeda, K. Motoyama, Y. Miyake and Y. Nishibayashi, Chem. Commun., 2012, 48, 9528 DOI: 10.1039/C2CC35262A

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