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Issue 79, 2012
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Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

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Abstract

A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand.

Graphical abstract: Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

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Article information


Submitted
21 Jul 2012
Accepted
13 Aug 2012
First published
30 Aug 2012

Chem. Commun., 2012,48, 9936-9938
Article type
Communication

Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

R. Shintani, T. Ito, M. Nagamoto, H. Otomo and T. Hayashi, Chem. Commun., 2012, 48, 9936
DOI: 10.1039/C2CC35259A

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