Issue 77, 2012
From the journal:

Chemical Communications

Facile synthesis of 2-pyrazolines and α,β-diamino ketonesvia regioselective ring-opening of hydrazone-tethered aziridines†

Zhen Zhang,a   De Wang,a   Yin Weib  and  Min Shi*ab  

* Corresponding authors

a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 MeiLong Road, Shanghai, 200237, P. R. China

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, P. R. China
E-mail: mshi@mail.sioc.ac.cn

Abstract

A facile strategy to access 2-pyrazolines and α,β-diamino ketones via SN2-type ring-opening of N-(aziridin-2-ylethylidene)hydrazines or N-(aziridin-2-ylbutylidene)hydrazines in the presence of Lewis acid or trifluoromethanesulfonic acid (TfOH) is described in this context.

Graphical abstract: Facile synthesis of 2-pyrazolines and α,β-diamino ketones via regioselective ring-opening of hydrazone-tethered aziridines

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Article information

DOI
https://doi.org/10.1039/C2CC35135H
Article type
Communication
Submitted
18 Jul 2012
Accepted
08 Aug 2012
First published
09 Aug 2012

Chem. Commun., 2012,48, 9607-9609

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Facile synthesis of 2-pyrazolines and α,β-diamino ketones via regioselective ring-opening of hydrazone-tethered aziridines

Z. Zhang, D. Wang, Y. Wei and M. Shi, Chem. Commun., 2012, 48, 9607 DOI: 10.1039/C2CC35135H

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