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Issue 85, 2012
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Nucleic acid aptamers: an emerging frontier in cancer therapy

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Abstract

The last two decades have witnessed the development and application of nucleic acid aptamers in a variety of fields, including target analysis, disease therapy, and molecular and cellular engineering. The efficient and widely applicable aptamer selection, reproducible chemical synthesis and modification, generally impressive target binding selectivity and affinity, relatively rapid tissue penetration, low immunogenicity, and rapid systemic clearance make aptamers ideal recognition elements for use as therapeutics or for in vivo delivery of therapeutics. In this feature article, we discuss the development and biomedical application of nucleic acid aptamers, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.

Graphical abstract: Nucleic acid aptamers: an emerging frontier in cancer therapy

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Article information


Submitted
13 Jul 2012
Accepted
21 Aug 2012
First published
21 Aug 2012

Chem. Commun., 2012,48, 10472-10480
Article type
Feature Article

Nucleic acid aptamers: an emerging frontier in cancer therapy

G. Zhu, M. Ye, M. J. Donovan, E. Song, Z. Zhao and W. Tan, Chem. Commun., 2012, 48, 10472
DOI: 10.1039/C2CC35042D

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