Issue 75, 2012

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Abstract

The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

Graphical abstract: Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Supplementary files

Article information

Article type
Communication
Submitted
11 Jul 2012
Accepted
25 Jul 2012
First published
30 Jul 2012

Chem. Commun., 2012,48, 9403-9405

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

P. Van de Vijver, L. Scheer, J. van Beijnum, A. Griffioen and T. M. Hackeng, Chem. Commun., 2012, 48, 9403 DOI: 10.1039/C2CC34956F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements