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Issue 72, 2012
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Semisynthetic peptide–lipase conjugates for improved biotransformations

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Abstract

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

Graphical abstract: Semisynthetic peptide–lipase conjugates for improved biotransformations

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Publication details

The article was received on 05 Jul 2012, accepted on 23 Jul 2012 and first published on 24 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34816K
Chem. Commun., 2012,48, 9053-9055

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    Semisynthetic peptide–lipase conjugates for improved biotransformations

    O. Romero, M. Filice, B. D. L. Rivas, C. Carrasco-Lopez, J. Klett, A. Morreale, J. A. Hermoso, J. M. Guisan, O. Abian and J. M. Palomo, Chem. Commun., 2012, 48, 9053
    DOI: 10.1039/C2CC34816K

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