Jump to main content
Jump to site search
Publishing
Advanced

Issue 72, 2012
Previous Article Next Article

Semisynthetic peptide–lipase conjugates for improved biotransformations

Oscar Romero,a  Marco Filice,a  Blanca de las Rivas,b  Cesar Carrasco-Lopez,c  Javier Klett,d  Antonio Morreale,d  Juan A. Hermoso,c  Jose M. Guisan,a  Olga Abiane  and  Jose M. Palomo*a 
Author affiliations

* Corresponding authors

a Departamento de Biocatálisis, Instituto de Catálisis (CSIC), Marie Curie 2. Cantoblanco. CampusUAM, 28049 Madrid, Spain
E-mail: josempalomo@icp.csic.es
Fax: +34 915854760

b Departamento de Biotecnología Microbiana, Instituto de Ciencia y Tecnología de alimentos y Nutrición, (ICTAN-CSIC), Madrid, Spain

c Departamento de Cristalografía y Biología Estructural, Instituto de Química-Física Rocasolano (CSIC), Madrid, Spain

d Unidad de Bioinformática, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

e Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, Zaragoza, Spain

Abstract

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

Graphical abstract: Semisynthetic peptide–lipase conjugates for improved biotransformations

Back to tab navigation
Download options Please wait...

Supplementary files

Publication details

The article was received on 05 Jul 2012, accepted on 23 Jul 2012 and first published on 24 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34816K
Chem. Commun., 2012,48, 9053-9055

  •   Request permissions

    Semisynthetic peptide–lipase conjugates for improved biotransformations

    O. Romero, M. Filice, B. D. L. Rivas, C. Carrasco-Lopez, J. Klett, A. Morreale, J. A. Hermoso, J. M. Guisan, O. Abian and J. M. Palomo, Chem. Commun., 2012, 48, 9053
    DOI: 10.1039/C2CC34816K

    If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.

    Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.
    • For reproduction of material from PCCP:
      Reproduced from Ref. XX with permission from the PCCP Owner Societies.
    • For reproduction of material from PPS:
      Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.
    • For reproduction of material from all other RSC journals and books:
      Reproduced from Ref. XX with permission from The Royal Society of Chemistry.

    If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".

    In all cases the Ref. XX is the XXth reference in the list of references.

    If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC
    • For reproduction of material from PCCP:
      [Original citation] - Reproduced by permission of the PCCP Owner Societies
    • For reproduction of material from PPS:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
    • For reproduction of material from all other RSC journals:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry

    If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements