Photodynamic activity of viral nanoparticles conjugated with C60

Amy M. Wen; Mary J. Ryan; Alice C. Yang; Kurt Breitenkamp; Jonathan K. Pokorski; Nicole F. Steinmetz

doi:10.1039/C2CC34695H

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Photodynamic activity of viral nanoparticles conjugated with C₆₀†

Amy M. Wen,^a Mary J. Ryan,^ab Alice C. Yang,^a Kurt Breitenkamp,^c Jonathan K. Pokorski^d and Nicole F. Steinmetz*^aef

Author affiliations

* Corresponding authors

^a Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, USA
E-mail: nicole.steinmetz@case.edu
Tel: +1 216 368 5590

^b Department of Chemical and Materials Engineering, School of Engineering, University of Dayton, Dayton, USA

^c Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA

^d Macromolecular Sciences and Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, USA

^e Radiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, USA

^f Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, USA

Abstract

The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C₆₀) and their photodynamic activity is described. VNP–C₆₀ conjugates were assembled using click chemistry. Cell uptake and cell killing using white light therapy and a prostate cancer cell line is demonstrated.

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Article information

DOI: https://doi.org/10.1039/C2CC34695H
Article type: Communication
Submitted: 04 May 2012
Accepted: 12 Jul 2012
First published: 16 Jul 2012

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Chem. Commun., 2012,48, 9044-9046

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Photodynamic activity of viral nanoparticles conjugated with C₆₀

A. M. Wen, M. J. Ryan, A. C. Yang, K. Breitenkamp, J. K. Pokorski and N. F. Steinmetz, Chem. Commun., 2012, 48, 9044 DOI: 10.1039/C2CC34695H

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Chemical Communications