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Issue 70, 2012
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Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling

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Abstract

A simple and fast electrochemical nucleic acid assay based on a target recycling strategy and the release of a double-stranded DNA intercalating redox probe upon digestion of a specific duplex by exonuclease III is demonstrated.

Graphical abstract: Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling

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Supplementary files

Article information


Submitted
23 Jun 2012
Accepted
04 Jul 2012
First published
05 Jul 2012

Chem. Commun., 2012,48, 8772-8774
Article type
Communication

Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling

R. Miranda-Castro, D. Marchal, B. Limoges and F. Mavré, Chem. Commun., 2012, 48, 8772 DOI: 10.1039/C2CC34511K

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