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Issue 78, 2012
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Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch

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Abstract

Conformational dynamics and observed equilibrium constants for ligand binding of the adenine-specific riboswitch (add-A riboswitch) in the absence of Mg2+ and presence of various concentrations of poly-ethylene glycol having an average molecular weight of 200 indicated that 54.2 water molecules were released from P2 and P3 stem regions of the add-A riboswitch during conformational transition upon the binding of 2-aminopurine, an analog of the natural ligand adenine.

Graphical abstract: Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch

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Publication details

The article was received on 23 Jun 2012, accepted on 19 Jul 2012 and first published on 19 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34506D
Chem. Commun., 2012,48, 9684-9686

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    Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch

    V. Kumar, T. Endoh, K. Murakami and N. Sugimoto, Chem. Commun., 2012, 48, 9684
    DOI: 10.1039/C2CC34506D

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