Issue 80, 2012
From the journal:

Chemical Communications

A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation†

Jongho Jeon,‡a   Kyung Hyun Lee‡a  and  Jianghong Rao*a  

* Corresponding authors

a Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Chemistry, Stanford University, Stanford, California 94305-5484, USA
E-mail: jrao@stanford.edu
Fax: +1 650 736 7925
Tel: +1 650 736 8563

Abstract

Fluorogenic sulforhodamine–neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250–400 fold enhancement in binding affinity relative to corresponding unconjugated fluorophores.

Graphical abstract: A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

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Article information

DOI
https://doi.org/10.1039/C2CC34498J
Article type
Communication
Submitted
22 Jun 2012
Accepted
23 Aug 2012
First published
24 Aug 2012

Chem. Commun., 2012,48, 10034-10036

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A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

J. Jeon, K. H. Lee and J. Rao, Chem. Commun., 2012, 48, 10034 DOI: 10.1039/C2CC34498J

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