Issue 68, 2012
From the journal:

Chemical Communications

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes†

David G. Smith,a   Brian K. McMahon,a   Robert Pala  and  David Parker*a  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
E-mail: david.parker@dur.ac.uk

Abstract

Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb–Eu complexes.

Graphical abstract: Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

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Article information

DOI
https://doi.org/10.1039/C2CC34267G
Article type
Communication
Submitted
14 Jun 2012
Accepted
10 Jul 2012
First published
11 Jul 2012

Chem. Commun., 2012,48, 8520-8522

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Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

D. G. Smith, B. K. McMahon, R. Pal and D. Parker, Chem. Commun., 2012, 48, 8520 DOI: 10.1039/C2CC34267G

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