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Issue 67, 2012
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Interactions of non-polar and “Click-able” nucleotides in the confines of a DNA polymerase active site

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Abstract

Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar “Click-able” nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.

Graphical abstract: Interactions of non-polar and “Click-able” nucleotides in the confines of a DNA polymerase active site

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Article information


Submitted
11 Jun 2012
Accepted
25 Jun 2012
First published
26 Jun 2012

Chem. Commun., 2012,48, 8320-8322
Article type
Communication

Interactions of non-polar and “Click-able” nucleotides in the confines of a DNA polymerase active site

S. Obeid, H. Bußkamp, W. Welte, K. Diederichs and A. Marx, Chem. Commun., 2012, 48, 8320
DOI: 10.1039/C2CC34181F

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