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Issue 62, 2012
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Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation

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Abstract

Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400–700 nm giving IC50 = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC50 = 3.3 ± 0.4 μM), while both are less toxic in the dark.

Graphical abstract: Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation

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Article information


Submitted
17 May 2012
Accepted
07 Jun 2012
First published
29 Jun 2012

Chem. Commun., 2012,48, 7702-7704
Article type
Communication

Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation

S. Banerjee, P. Prasad, A. Hussain, I. Khan, P. Kondaiah and A. R. Chakravarty, Chem. Commun., 2012, 48, 7702
DOI: 10.1039/C2CC33576J

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