Issue 66, 2012

The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

Abstract

An unprecedented direct reductive amination of electron-deficient amines such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, Ar2PO-, etc. protected amines with aldehydes is achieved using the Re2O7 catalyst and silanes as the hydride source. Excellent regioselective mono-alkylation and chemoselective reductive-amination were observed.

Graphical abstract: The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

Supplementary files

Article information

Article type
Communication
Submitted
03 May 2012
Accepted
02 Jul 2012
First published
02 Jul 2012

Chem. Commun., 2012,48, 8276-8278

The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

B. G. Das and P. Ghorai, Chem. Commun., 2012, 48, 8276 DOI: 10.1039/C2CC33185C

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