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Issue 56, 2012
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Intramolecular hydrogen bonding-assisted cyclocondensation of α-diazoketones with various amines: a strategy for highly efficient Wolff 1,2,3-triazole synthesis

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Abstract

A catalytic and highly efficient Wolff's cyclocondensation of α-diazoketones with aromatic and aliphatic amines has been realized for the first time by utilizing the strategy of an intramolecular hydrogen bonding-activating carbonyl group. This approach successfully solved the challenging problem of poor condensation efficiency in Wolff 1,2,3-triazole synthesis, and constitutes a powerful method for the synthesis of highly functionalized 1,2,3-triazoles.

Graphical abstract: Intramolecular hydrogen bonding-assisted cyclocondensation of α-diazoketones with various amines: a strategy for highly efficient Wolff 1,2,3-triazole synthesis

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Article information


Submitted
02 May 2012
Accepted
23 May 2012
First published
24 May 2012

Chem. Commun., 2012,48, 7076-7078
Article type
Communication

Intramolecular hydrogen bonding-assisted cyclocondensation of α-diazoketones with various amines: a strategy for highly efficient Wolff 1,2,3-triazole synthesis

Z. Wang, X. Bi, P. Liao, R. Zhang, Y. Liang and D. Dong, Chem. Commun., 2012, 48, 7076
DOI: 10.1039/C2CC33157H

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