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Issue 61, 2012
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Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

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Abstract

A concise synthesis of polycyclic pyrroloindolines from simple malonic diamides via an intramolecular oxidative coupling/condensative cyclization cascade process is reported. The reaction provides an efficient method to construct polycyclic pyrroloindolines in good to excellent yields, which should be useful in the synthesis of natural products and pharmaceutical molecules.

Graphical abstract: Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

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Supplementary files

Article information


Submitted
01 May 2012
Accepted
07 Jun 2012
First published
08 Jun 2012

Chem. Commun., 2012,48, 7571-7573
Article type
Communication

Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

F. Fan, W. Xie and D. Ma, Chem. Commun., 2012, 48, 7571
DOI: 10.1039/C2CC33129B

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