Issue 71, 2012
From the journal:

Chemical Communications

A modular synthesis of dithiocarbamate pendant unnatural α-amino acids†

Amit Saha,‡a   R. B. Nasir Baig,‡a   John Leazer*a  and  Rajender S. Varma*a  

* Corresponding authors

a Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, 26 West Martin Luther King Drive, MS 443, Cincinnati, USA
E-mail: Varma.Rajender@epa.gov, Leazer.John@epa.gov
Fax: +1 513-569-7677
Tel: +1 513-487-2701

Abstract

Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.

Graphical abstract: A modular synthesis of dithiocarbamate pendant unnatural α-amino acids

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Article information

DOI
https://doi.org/10.1039/C2CC32894A
Article type
Communication
Submitted
23 Apr 2012
Accepted
29 Jun 2012
First published
29 Jun 2012

Chem. Commun., 2012,48, 8889-8891

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A modular synthesis of dithiocarbamate pendant unnatural α-amino acids

A. Saha, R. B. N. Baig, J. Leazer and R. S. Varma, Chem. Commun., 2012, 48, 8889 DOI: 10.1039/C2CC32894A

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