Issue 54, 2012
From the journal:

Chemical Communications

Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity†

Dokyoung Kim,a   Sunderraman Sambasivan,a   Hyoseok Nam,b   Ki Hean Kim,*b   Jin Yong Kim,c   Taiha Joo,*c   Kyung-Ha Lee,d   Kyong-Tai Kim*d  and  Kyo Han Ahn*a  

* Corresponding authors

a Department of Chemistry, Center for Electro-Photo Behaviors in Advanced Molecular Systems, POSTECH, San 31, Hyoja-dong, Pohang, Republic of Korea
E-mail: ahn@postech.ac.kr

b Department of Mechanical Engineering and Division of Integrative Biosciences and Biotechnology, POSTECH, San 31, Hyoja-dong, Pohang, Republic of Korea

c Department of Chemistry, POSTECH, San 31, Hyoja-dong, Pohang, Republic of Korea

d Department of Life Science, POSTECH, San 31, Hyoja-dong, Pohang, Republic of Korea

Abstract

Reaction-based fluorescent probes for monoamine oxidases A and B are developed based on a new two-photon absorbing compound and its precursor. The probes show turn-on fluorescence response to the enzymes owing to the two-photon absorbing compound produced by the enzymatic activity, as monitored by one- as well as two-photon microscopy for the first time.

Graphical abstract: Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity

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Article information

DOI
https://doi.org/10.1039/C2CC32424E
Article type
Communication
Submitted
04 Apr 2012
Accepted
15 May 2012
First published
16 May 2012

Chem. Commun., 2012,48, 6833-6835

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Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity

D. Kim, S. Sambasivan, H. Nam, K. Hean Kim, J. Yong Kim, T. Joo, K. Lee, K. Kim and K. Han Ahn, Chem. Commun., 2012, 48, 6833 DOI: 10.1039/C2CC32424E

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