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Issue 76, 2012
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A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

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Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Graphical abstract: A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

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Publication details

The article was received on 28 Mar 2012, accepted on 31 May 2012 and first published on 07 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC32253F
Chem. Commun., 2012,48, 9462-9464

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    A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

    H. He, D. S. Chan, C. Leung and D. Ma, Chem. Commun., 2012, 48, 9462
    DOI: 10.1039/C2CC32253F

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