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Issue 51, 2012
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DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

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Abstract

Using the DNA-based catalysis concept, a novel Cu(II) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-additions.

Graphical abstract: DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

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Article information


Submitted
13 Mar 2012
Accepted
08 May 2012
First published
08 May 2012

Chem. Commun., 2012,48, 6366-6368
Article type
Communication

DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

R. P. Megens and G. Roelfes, Chem. Commun., 2012, 48, 6366
DOI: 10.1039/C2CC31854G

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