Issue 44, 2012

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

Abstract

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines were developed using a bifunctional catalyst readily prepared from L-leucine. The chiral benzylic amine products were obtained in high yields (up to 96% yield) and good to high enantiomeric excesses (up to 95% ee).

Graphical abstract: Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

  • This article is part of the themed collection: Chirality

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2012
Accepted
14 Apr 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5518-5520

Enantioselective Friedel–Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst

G. Li and J. Qu, Chem. Commun., 2012, 48, 5518 DOI: 10.1039/C2CC31735D

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