Issue 42, 2012
From the journal:

Chemical Communications

Highly biocompatible, hollow coordination polymernanoparticles as cisplatin carriers for efficient intracellular drug delivery†

Hong-Yuan Lian,a   Ming Hu,b   Chia-Hung Liu,c   Yusuke Yamauchi*bd  and  Kevin C.-W. Wu*ae  

* Corresponding authors

a Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
E-mail: kevinwu@ntu.edu.tw
Fax: +886 2 2362 3040
Tel: +886 2 3366 3064

b World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Japan
E-mail: YAMAUCHI.Yusuke@nims.go.jp

c Department of Urology, Taipei Medical University-Shuang Ho Hospital, No. 291, Jhongjheng Rd., Jhonghe Dist., New Taipei City 23561, Taiwan

d Faculty of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku, Tokyo 169-8555, Japan

e Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Taiwan

Abstract

Highly biocompatible coordination polymer (Prussian Blue) nanoparticles (LC50 > 1000 μg mL−1) with a hollow interior and a microporous framework (denoted as HPB) are utilized as an anticancer drug (i.e. cisplatin) capsule for chemotherapy of bladder cancer T24 cells.

Graphical abstract: Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/C2CC31708G
Article type
Communication
Submitted
07 Mar 2012
Accepted
27 Mar 2012
First published
18 Apr 2012

Chem. Commun., 2012,48, 5151-5153

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Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular drug delivery

H. Lian, M. Hu, C. Liu, Y. Yamauchi and K. C.-W. Wu, Chem. Commun., 2012, 48, 5151 DOI: 10.1039/C2CC31708G

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