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Issue 53, 2012
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Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe

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Abstract

We report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe was discovered through a high-content image based screening of 160 members of the chalcone library. Interestingly, the molecular binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.

Graphical abstract: Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe

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Article information


Submitted
06 Mar 2012
Accepted
11 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 6681-6683
Article type
Communication

Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe

S. Lee, N. Kang, S. Park, S. Yun, Y. Chandran and Y. Chang, Chem. Commun., 2012, 48, 6681
DOI: 10.1039/C2CC31662E

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