Issue 42, 2012
From the journal:

Chemical Communications

The yields of transcripts for a RNA polymerase regulated by hairpin structures in nascent RNAs†

Satoru Nagatoishi,a   Ryoya Onob  and  Naoki Sugimoto*ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

b Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1457

Abstract

The yields of transcripts capable of forming RNA hairpins with different stem lengths at elongation phase were determined in a T7 RNA polymerase. The amount of RNA transcripts decreased with stem length, demonstrating that transcriptional efficiency is regulated by secondary structure formation in the nascent RNA.

Graphical abstract: The yields of transcripts for a RNA polymerase regulated by hairpin structures in nascent RNAs

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Article information

DOI
https://doi.org/10.1039/C2CC31657A
Article type
Communication
Submitted
06 Mar 2012
Accepted
30 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 5121-5123

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The yields of transcripts for a RNA polymerase regulated by hairpin structures in nascent RNAs

S. Nagatoishi, R. Ono and N. Sugimoto, Chem. Commun., 2012, 48, 5121 DOI: 10.1039/C2CC31657A

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