Issue 45, 2012
From the journal:

Chemical Communications

Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation†‡

Mats Linder,a   Adam Johannes Johansson,a   Bianca Manta,§a   Philip Olssona  and  Tore Brinck*a  

* Corresponding authors

a Applied Physical Chemistry, KTH Royal Institute of Technology, Teknikringen 30-36, S-10044 Stockholm, Sweden
E-mail: tore@physchem.kth.se
Tel: +46 8 7908210

Abstract

We present and evaluate a new and potentially efficient route for enzyme-mediated Diels–Alder reactions, utilizing general acid–base catalysis. The viability of employing the active site of ketosteroid isomerase is demonstrated.

Graphical abstract: Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation

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Article information

DOI
https://doi.org/10.1039/C2CC31502E
Article type
Communication
Submitted
28 Feb 2012
Accepted
30 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 5665-5667

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Envisioning an enzymatic Diels–Alder reaction by in situ acid–base catalyzed diene generation

M. Linder, A. J. Johansson, B. Manta, P. Olsson and T. Brinck, Chem. Commun., 2012, 48, 5665 DOI: 10.1039/C2CC31502E

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