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Issue 38, 2012
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Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

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Abstract

The chiral phosphoric acid-catalyzed enantioselective reductive amination of aliphatic ketones with aromatic amines was successfully achieved by the use of benzothiazoline as the hydrogen donor. Corresponding chiral aliphatic amines were obtained with excellent enantioselectivities.

Graphical abstract: Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

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Supplementary files

Article information


Submitted
28 Feb 2012
Accepted
17 Mar 2012
First published
19 Mar 2012

Chem. Commun., 2012,48, 4573-4575
Article type
Communication

Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

K. Saito and T. Akiyama, Chem. Commun., 2012, 48, 4573
DOI: 10.1039/C2CC31486J

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