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Issue 39, 2012

Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones

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Abstract

The first Mannich reaction employing phthalides using a quinidine-based multifunctional catalyst has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with good diastereo- and enantioselectivities. Convenient synthesis of chiral isoquinolinones and isoquinolines has also been demonstrated.

Graphical abstract: Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones

Supplementary files

Article information


Submitted
27 Feb 2012
Accepted
15 Mar 2012
First published
15 Mar 2012

Chem. Commun., 2012,48, 4707-4709
Article type
Communication

Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones

J. Luo, H. Wang, F. Zhong, J. Kwiatkowski, L. Xu and Y. Lu, Chem. Commun., 2012, 48, 4707 DOI: 10.1039/C2CC31439H

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