Jump to main content
Jump to site search

Issue 37, 2012
Previous Article Next Article

Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates

Author affiliations

Abstract

The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of imidazoles to take part in iminium-activated aza-Michael additions to enals.

Graphical abstract: Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Feb 2012, accepted on 13 Mar 2012 and first published on 13 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31224G
Citation: Chem. Commun., 2012,48, 4504-4506

  •   Request permissions

    Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates

    S. Lakhdar, M. Baidya and H. Mayr, Chem. Commun., 2012, 48, 4504
    DOI: 10.1039/C2CC31224G

Search articles by author

Spotlight

Advertisements