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Issue 42, 2012
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An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

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Abstract

An efficient organocatalytic Michael-aldol cascade reaction for the asymmetric synthesis of spirocyclic oxindole derivatives fused with tetrahydrothiophenes has been developed through a formal [3+2] annulation strategy.

Graphical abstract: An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

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Article information


Submitted
09 Feb 2012
Accepted
05 Mar 2012
First published
05 Mar 2012

Chem. Commun., 2012,48, 5160-5162
Article type
Communication

An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives

S. Duan, Y. Li, Y. Liu, Y. Zou, D. Shi and W. Xiao, Chem. Commun., 2012, 48, 5160
DOI: 10.1039/C2CC30931A

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