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Issue 37, 2012
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Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

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Abstract

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives.

Graphical abstract: Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

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Article information


Submitted
06 Feb 2012
Accepted
19 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4444-4446
Article type
Communication

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

M. J. Weissenborn, R. Castangia, J. W. Wehner, R. Šardzík, T. K. Lindhorst and S. L. Flitsch, Chem. Commun., 2012, 48, 4444
DOI: 10.1039/C2CC30844D

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