A water soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

Christelle Gaulier; Audrey Hospital; Bertrand Legeret; Agnès F. Delmas; Vincent Aucagne; Federico Cisnetti; Arnaud Gautier

doi:10.1039/C2CC30515A

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A water soluble Cu^I–NHC for CuAAC ligation of unprotected peptides under open air conditions†

Christelle Gaulier,^a Audrey Hospital,^a Bertrand Legeret,^a Agnès F. Delmas,^b Vincent Aucagne,^b Federico Cisnetti^a and Arnaud Gautier*^a

Author affiliations

* Corresponding authors

^a Institut de Chimie de Clermont-Ferrand, CNRS UMR 6296, Clermont-Université, 24 Ave des Landais, F-63177 Aubière, France
E-mail: arnaud.gautier@univ-bpclermont.fr
Fax: +33 (0)4 73 40 77 17
Tel: +33 (0)4 73 40 76 46

^b Centre de Biophysique Moléculaire, CNRS UPR 4301, Rue Charles Sadron, F-45071 Orléans cedex 2, France

Abstract

A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable Cu^I–NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.

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Article information

DOI: https://doi.org/10.1039/C2CC30515A
Article type: Communication
Submitted: 23 Jan 2012
Accepted: 28 Feb 2012
First published: 28 Feb 2012

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Chem. Commun., 2012,48, 4005-4007

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A water soluble Cu^I–NHC for CuAAC ligation of unprotected peptides under open air conditions

C. Gaulier, A. Hospital, B. Legeret, A. F. Delmas, V. Aucagne, F. Cisnetti and A. Gautier, Chem. Commun., 2012, 48, 4005 DOI: 10.1039/C2CC30515A

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