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Issue 33, 2012
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A water soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

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Abstract

A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable CuI–NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.

Graphical abstract: A water soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

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Supplementary files

Article information


Submitted
23 Jan 2012
Accepted
28 Feb 2012
First published
28 Feb 2012

Chem. Commun., 2012,48, 4005-4007
Article type
Communication

A water soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

C. Gaulier, A. Hospital, B. Legeret, A. F. Delmas, V. Aucagne, F. Cisnetti and A. Gautier, Chem. Commun., 2012, 48, 4005
DOI: 10.1039/C2CC30515A

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