Issue 31, 2012
From the journal:

Chemical Communications

A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic†

Andrew G. Jamieson,*a   David Russellb  and  Andrew D. Hamilton*c  

* Corresponding authors

a Department of Chemistry, University of Leicester, Leicester, UK
E-mail: andrew.jamieson@le.ac.uk
Fax: +44 (0)116 252 3789
Tel: +44 (0)116 252 2105

b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

c University of Oxford, Chemistry Research Laboratory, Mansfield Rd, Oxford OX1 3TA, UK
E-mail: andrew.hamilton@chem.ox.ac.uk
Tel: +44 (0)1865 270242

Abstract

A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

Graphical abstract: A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

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Article information

DOI
https://doi.org/10.1039/C2CC30295K
Article type
Communication
Submitted
13 Jan 2012
Accepted
16 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3709-3711

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A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

A. G. Jamieson, D. Russell and A. D. Hamilton, Chem. Commun., 2012, 48, 3709 DOI: 10.1039/C2CC30295K

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