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Issue 34, 2012
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Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

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Abstract

The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.

Graphical abstract: Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

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Article information


Submitted
12 Jan 2012
Accepted
28 Feb 2012
First published
29 Feb 2012

Chem. Commun., 2012,48, 4064-4066
Article type
Communication

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

M. W. Jones, R. A. Strickland, F. F. Schumacher, S. Caddick, James. R. Baker, M. I. Gibson and D. M. Haddleton, Chem. Commun., 2012, 48, 4064 DOI: 10.1039/C2CC30259D

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