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Issue 30, 2012

Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates

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Abstract

The first asymmetric synthesis of β-trifluoromethylated pyrroline carboxylates has been achieved by organocatalytic conjugated addition of adamantyl glycine imine to β-trifluoromethylated enones, followed by a deprotection/cyclization/dehydration sequence.

Graphical abstract: Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates

Supplementary files

Article information


Submitted
23 Dec 2011
Accepted
15 Feb 2012
First published
15 Feb 2012

Chem. Commun., 2012,48, 3632-3634
Article type
Communication

Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates

H. Kawai, Y. Sugita, E. Tokunaga, H. Sato, M. Shiro and N. Shibata, Chem. Commun., 2012, 48, 3632 DOI: 10.1039/C2CC18052A

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