Issue 20, 2012
From the journal:

Chemical Communications

Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents†

Robert B. P. Elmes,ac   Marialuisa Erby,bc   Sandra A. Bright,bc   D. Clive Williams*bc  and  Thorfinnur Gunnlaugsson*ac  

* Corresponding authors

a School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland
E-mail: gunnlaut@tcd.ie
Fax: +353 1671 2826
Tel: +353 1896 3459

b School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
E-mail: clive.williams@tcd.ie

c Trinity College Biomedical Sciences Institute, Dublin 2, Ireland

Abstract

The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.

Graphical abstract: Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

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Article information

DOI
https://doi.org/10.1039/C2CC17274G
Article type
Communication
Submitted
22 Nov 2011
Accepted
13 Jan 2012
First published
17 Jan 2012

Chem. Commun., 2012,48, 2588-2590

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Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

R. B. P. Elmes, M. Erby, S. A. Bright, D. C. Williams and T. Gunnlaugsson, Chem. Commun., 2012, 48, 2588 DOI: 10.1039/C2CC17274G

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