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Issue 18, 2012
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Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

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Abstract

We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.

Graphical abstract: Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

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Article information


Submitted
20 Nov 2011
Accepted
04 Jan 2012
First published
06 Jan 2012

Chem. Commun., 2012,48, 2400-2402
Article type
Communication

Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

A. Curcio, R. Marotta, A. Riedinger, D. Palumberi, A. Falqui and T. Pellegrino, Chem. Commun., 2012, 48, 2400
DOI: 10.1039/C2CC17223B

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