Issue 13, 2012

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Abstract

We report the first example of highly enantioselective organocatalytic synthesis of 3-difluoroalkyl substituted 3-hydroxyoxindoles. The total synthesis of the difluoro analogue of convolutamydine E was achieved by this method.

Graphical abstract: Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Supplementary files

Article information

Article type
Communication
Submitted
17 Nov 2011
Accepted
16 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 1919-1921

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Y. Liu and J. Zhou, Chem. Commun., 2012, 48, 1919 DOI: 10.1039/C2CC17140F

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