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Issue 23, 2012
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Spontaneous inter-conversion of insulin fibril chirality

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Abstract

Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.

Graphical abstract: Spontaneous inter-conversion of insulin fibril chirality

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Publication details

The article was received on 07 Nov 2011, accepted on 14 Dec 2011 and first published on 14 Dec 2011


Article type: Communication
DOI: 10.1039/C2CC16895B
Citation: Chem. Commun., 2012,48, 2837-2839

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    Spontaneous inter-conversion of insulin fibril chirality

    D. Kurouski, R. K. Dukor, X. Lu, L. A. Nafie and I. K. Lednev, Chem. Commun., 2012, 48, 2837
    DOI: 10.1039/C2CC16895B

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