Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex

Caixia Yuan; Miaoli Zhu; Qingming Wang; Liping Lu; Shu Xing; Xueqi Fu; Zheng Jiang; Shuo Zhang; Zongwei Li; Zhuoyu Li; Ruiting Zhu; Ling Ma; Liqing Xu

doi:10.1039/C2CC16818A

Potent and selective inhibition of T-cell proteintyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex†

Caixia Yuan,^a Miaoli Zhu,*^ac Qingming Wang,^a Liping Lu,*^a Shu Xing,^b Xueqi Fu,*^b Zheng Jiang,^c Shuo Zhang,^c Zongwei Li,^d Zhuoyu Li,^d Ruiting Zhu,^a Ling Ma^a and Liqing Xu^a

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* Corresponding authors

^a Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, P.R. China
E-mail: miaoli@sxu.edu.cn, luliping@sxu.edu.cn

^b Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun 130023, P.R. China
E-mail: fxq@jlu.edu.cn

^c Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, P.R. China

^d Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, P.R. China

Abstract

A dinuclear Cu(II) complex, [Cu₂(μ-IDA)(phen)₃(NO₃)]NO₃·4H₂O (phen = 1,10-phenanthroline, H₂IDA = iminodiacetic acid), was found to potently and selectively inhibit T-cell protein tyrosine phosphatase, and lead to the anti-proliferation and apoptosis of C6 glioma cells.

Chemical Communications

Potent and selective inhibition of T-cell proteintyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex†

Abstract

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Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex

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