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Issue 30, 2012
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Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

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Abstract

Investigation of the hydrolysis of dinucleoside-arsenate-deoxyguanylyl-3′,5′-deoxyguanosine (dGAsdG) reveals that base-stacking in DNA increases the resistance of As–DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As–DNA is found to be endothermic. The hydrolysis stability of As–DNA should be higher than that estimated based on arsenate diester models.

Graphical abstract: Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

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Publication details

The article was received on 24 Oct 2011, accepted on 16 Feb 2012 and first published on 17 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC16600C
Chem. Commun., 2012,48, 3626-3628

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    Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

    J. Wang, J. Gu and J. Leszczynski, Chem. Commun., 2012, 48, 3626
    DOI: 10.1039/C2CC16600C

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