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Issue 2, 2012
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Regioselective C–H bond functionalizations of acridines using organozinc reagents

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Abstract

Despite the recent advance in C–H bond functionalization chemistry, the C–H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C–H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.

Graphical abstract: Regioselective C–H bond functionalizations of acridines using organozinc reagents

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Publication details

The article was received on 24 Oct 2011, accepted on 08 Nov 2011 and first published on 09 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16582H
Chem. Commun., 2012,48, 308-310

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    Regioselective C–H bond functionalizations of acridines using organozinc reagents

    I. Hyodo, M. Tobisu and N. Chatani, Chem. Commun., 2012, 48, 308
    DOI: 10.1039/C1CC16582H

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