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Issue 4, 2012
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Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

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Abstract

Cleavage agents showed cleavage yields as much as 9–14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents.

Graphical abstract: Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

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Publication details

The article was received on 10 Oct 2011, accepted on 11 Nov 2011 and first published on 23 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16293D
Chem. Commun., 2012,48, 588-590

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    Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis

    K. Jeong, H. R. Cho, S. H. Choi, Y. Park and P. S. Chae, Chem. Commun., 2012, 48, 588
    DOI: 10.1039/C1CC16293D

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