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Issue 10, 2012
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Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

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Abstract

The four DNA bases are recognized in immobilized DNA strands at high alkaline pH by nanopore current recordings. Ionic currents through the biological nanopores are also employed to measure the apparent pKa values of single nucleobases within the immobilised DNA strands.

Graphical abstract: Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

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Publication details

The article was received on 01 Oct 2011, accepted on 07 Nov 2011 and first published on 17 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16124E
Citation: Chem. Commun., 2012,48, 1520-1522

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    Nucleobase recognition at alkaline pH and apparent pKa of single DNA bases immobilised within a biological nanopore

    L. Franceschini, E. Mikhailova, H. Bayley and G. Maglia, Chem. Commun., 2012, 48, 1520
    DOI: 10.1039/C1CC16124E

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