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Issue 1, 2012
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Synthesis of 1,2,3-triazole-fused heterocycles viaPd-catalyzed cyclization of 5-iodotriazoles

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Abstract

A convenient approach toward polycyclic frameworks containing fused 1,2,3-triazoles is described. The synthesis consists of a Cu-catalyzed cycloaddition and an intramolecular Pd-catalyzed direct arylation or Heck reaction, and affords the products in good to excellent yields.

Graphical abstract: Synthesis of 1,2,3-triazole-fused heterocycles viaPd-catalyzed cyclization of 5-iodotriazoles

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Publication details

The article was received on 30 Sep 2011, accepted on 21 Oct 2011 and first published on 14 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16110E
Chem. Commun., 2012,48, 55-57

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    Synthesis of 1,2,3-triazole-fused heterocycles viaPd-catalyzed cyclization of 5-iodotriazoles

    J. M. Schulman, A. A. Friedman, J. Panteleev and M. Lautens, Chem. Commun., 2012, 48, 55
    DOI: 10.1039/C1CC16110E

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